The maximum payload length typically delivered by AAV vectors is **around 4.7 kb**. This limit is a significant constraint in gene therapy design, as larger constructs can encounter packaging inefficiencies and reduced transduction effectiveness<sup class='text_citation' source_id='1' start_phrase='the AAV packaging capacity' end_phrase='making ...'></sup><sup class='text_citation' source_id='3' start_phrase='AAV vector genomes are been limited' end_phrase='effective payload delivery.'></sup>.

What is the maximum payload length in bases typically delivered by AAV vectors?

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