Organoid intelligence (OI) is described as an emerging field aiming to expand the definition of biocomputing toward brain-directed OI computing, i.e. to leverage the self-assembled machinery of 3D human brain cell cultures (brain organoids) to memorize and compute inputs[1]. It aims to establish OI as a form of genuine biological computing that harnesses brain organoids using scientific and bioengineering advances in an ethically responsible manner[1]. OI computing stresses its complementarity to AI, where computers aim to perform tasks done by brains, often by modeling our understanding of learning[1]. While AI aims to make computers more brain-like, OI research will explore how a 3D brain cell culture can be made more computer-like[1].
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