A Phase 1 trial of the well-known senolytic combination of dasatinib and quercetin in patients with Alzheimer's disease has been published in Neurotherapeutics.
Preclinical studies indicate an age-associated accumulation of senescent cells across multiple organ systems. Emerging evidence suggests that tau prot…
The Translational Geroscience Network ... Phase 2 trials using senolytic compounds, such as Dasatinib, Quercetin, and Fisetin, for the treatment of sepsis, chronic kidney disease, ...
Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate w…
Researchers publish the first data on the treatment of an age-related disease with drugs called senolytics. The results in patients with deadly idiopathic pulmonary fibrosis are en...
Even more troubling are recent ... that senescent cells themselves seem to have some beneficial functions, as opposed to being loafing cellular deadweight, and that if you did find...
Cellular senescence is a fundamental mechanism in aging, marked by irreversible growth arrest and diverse functional changes, including, but not limited to, the development of a se...
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